Extended Data Fig. 2: Aβ and tau PET association in separate models. | Nature Neuroscience

Extended Data Fig. 2: Aβ and tau PET association in separate models.

From: Proteomic changes in Alzheimer’s disease associated with progressive Aβ plaque and tau tangle pathologies

Extended Data Fig. 2

a, b, Standardized beta coefficients from linear models relating AD fibrillar pathology at baseline (Aβ- and tau-PET SUVR included separately in different models) and over time (Aβ- and tau-PET rate of change included separately in different models) to the CSF protein levels of the 128 differentially expressed proteins. Models included age, sex, mean overall protein level as covariates. There was no significant associations with Aβ-PET rate of change, and thus those results are not displayed. Results in panel a included all CU and MCI participants. Results in panel b were restricted to Aβ-positive CU and MCI participants. All linear regressions performed were two-sided, and p-values were adjusted for false discovery rate. * corresponds to pFDR < 0.05, ** corresponds to pFDR < 0.01, *** corresponds to pFDR < 0.001 Aβ = beta-amyloid; CU = cognitively unimpaired; MCI = mild cognitive impairment.

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