Extended Data Fig. 3: Pericytes and smooth muscle cells express CaV1.2 L-type Ca2+ channels. | Nature Neuroscience

Extended Data Fig. 3: Pericytes and smooth muscle cells express CaV1.2 L-type Ca2+ channels.

From: Inhibiting Ca2+ channels in Alzheimer’s disease model mice relaxes pericytes, improves cerebral blood flow and reduces immune cell stalling and hypoxia

Extended Data Fig. 3

a-d Single-cell RNA sequencing in mouse cortex (left bar chart) and histology of human cortex (black labeling on right images), respectively, reveal pericyte (PC) expression of CaV1.2 (a) but little or no expression of CaV1.3 (b), CaV1.1 (c) or CaV1.4 (d). Abbreviations: mRNA level (counts), venous smooth muscle cells (vSMCs), arteriolar SMCs (aSMCs), arterial SMCs (aaSMCs), microglia (MG), two fibroblast classes (FB1, FB2), oligodendrocytes (OL), three classes of broadly distributed endothelial cells (EC1-EC3), venous ECs (vEC), capillary ECs (capilEC), arterial ECs (aEC), and astrocytes (AC). Data obtained from refs. 43,94 (v23.proteinatlas.org). e Single-cell RNA sequencing of the BBB in patients with AD or control individuals (with no cognitive impairment) indicates that CaV1.2 is expressed in pericytes (T-PC, M-PC) and SMCs (aSMC, aaSMC), although with some decrease in AD (red arrows). Other abbreviations: arterial (ART), capillary (CAP), venous (VEN), perivascular fibroblast (P.FB), meningeal fibroblast (M.FB), T cell (TC), Ependymal (EPEN), astrocyte-hippocampus (AST-Hpc), astrocyte-cortex (AST-Ctx), perivascular macrophage (PM), microglia (MG), oligodendrocyte (OL), Oligodendrocyte Precursor Cell (OPC), Neuron (NEU). Data from ref. 95. Error bars are s.e.m.

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