Extended Data Fig. 9: Putative pathway by which ApoE4 in BAM induces vascular oxidative stress, neurovascular dysfunction and enhanced white matter injury. | Nature Neuroscience

Extended Data Fig. 9: Putative pathway by which ApoE4 in BAM induces vascular oxidative stress, neurovascular dysfunction and enhanced white matter injury.

From: A cell-autonomous role for border-associated macrophages in ApoE4 neurovascular dysfunction and susceptibility to white matter injury

Extended Data Fig. 9

(1) ApoE4 in BAM acts on ApoE receptors, for example, LRP1 as a candidate receptor, to increase intracellular Ca2+ in BAM in a cell autonomous manner resulting in NOX activation, (2) vascular oxidative stress, and (3) neurovascular dysfunction and reduced cerebral perfusion, which, in turn, leads to (4) enhanced white matter damage and cognitive impairment.

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