Extended Data Fig. 1: Effect of rApoE4 in ApoE−/− or CD36−/− mice, and of VLDL receptor antibodies and sex in ApoE4-TR mice. | Nature Neuroscience

Extended Data Fig. 1: Effect of rApoE4 in ApoE−/− or CD36−/− mice, and of VLDL receptor antibodies and sex in ApoE4-TR mice.

From: A cell-autonomous role for border-associated macrophages in ApoE4 neurovascular dysfunction and susceptibility to white matter injury

Extended Data Fig. 1

a. Topical application of rApoE4 (10 µg/ml), but not rApoE3 (10 µg/ml), leads to neurovascular dysfunction in ApoE−/− mice, prevented by CLO. b. Superfusion with VLDL receptor blocking antibodies (anti-VLDLr; 500 nM) fails to prevent the neurovascular dysfunction in ApoE4-TR mice, while RAP superfusion (200 nM) is effective. c. rApoE4 induces neurovascular dysfunction in mice lacking CD36. d. The detrimental neurovascular effects of ApoE4 are not sexually dimorphic. Data were analyzed using one-way or two-way ANOVA with Tukey’s or paired two-tailed t-test and are presented as mean±SEM. N = 5/group.

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