Extended Data Fig. 3: Macrophage/ microglia promote angiogenesis in the ventricular zone (VZ) of the ganglionic eminences. | Nature Neuroscience

Extended Data Fig. 3: Macrophage/ microglia promote angiogenesis in the ventricular zone (VZ) of the ganglionic eminences.

From: Proinflammatory immune cells disrupt angiogenesis and promote germinal matrix hemorrhage in prenatal human brain

Extended Data Fig. 3

(a) Schematic diagram showing three schedules of CSF1R inhibitor PLX5622 injection in pregnant mouse dams. (b, d, f) Transient inhibition of CSF1R leads to significant depletion of IBA1+ cells in the VZ of GE (b), VZ/SVZ of the pallium (d), and the CP (f). (c, e, g) Quantification of densities of IBA+ cells and IB4+ blood vessels in the VZ of GE (c), VZ/SVZ of the pallium (e), and the CP (g). Dashed lines indicate the regions in which quantifications are performed. Statistics in panels c, e, and g use two-tailed, unpaired Student’s t-test, data represent mean ± SEM. ns, not significant. n indicates the number of independent biological samples used for quantification.

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