Extended Data Fig. 9: Exposure to proinflammatory factors ELANE and CXCL16 promotes intraventricular hemorrhage in embryonic mouse brain. | Nature Neuroscience

Extended Data Fig. 9: Exposure to proinflammatory factors ELANE and CXCL16 promotes intraventricular hemorrhage in embryonic mouse brain.

From: Proinflammatory immune cells disrupt angiogenesis and promote germinal matrix hemorrhage in prenatal human brain

Extended Data Fig. 9

(a) Confocal microscopic images show intraventricular hemorrhage, characterized by the presence of Ter119+ red blood cells (RBCs) in the lateral ventricle adjacent to the medial ganglionic eminence (MGE). LV, lateral ventricle, IB4, isolectin B4, a vascular marker. (b) Quantification shows significantly higher numbers of RBCs and IBA1+ cells in the lateral ventricle, and subtle increases of RBCs and IBA1+ cells in the meninges over the cortical plate. Statistics use two-tailed, unpaired Student’s t-test, data represent mean ± SEM. ns, not significant. n indicates the number of independent biological samples used for quantification.

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