Extended Data Fig. 8: Block structure sufficient to maintain circuit function.

a. Position sensitivities (top, middle) and eigenvalues (bottom) for 100 networks in which all synapses within modO were shuffled while maintaining the in-degree and out-degree of each cell. In the top row, the position sensitivities of all shuffled networks (green) are compared to the actual network (gray) for each cell class (VPNI, Ve², ABD). In the middle row, shuffled networks (x-axis) are compared to the actual network (y-axis) on a cell-by-cell basis, with the colors indicating which block each cell belonged to and opacity indicating the relative frequency of the eye position sensitivities produced for each cell across all of the shuffles. b. Same as a except that modO was partitioned into two blocks using a stochastic block model (SBM) and each group of synapses within each block and between each pair of blocks was shuffled separately. c. Same as b, but for 7 blocks instead of two.