Extended Data Fig. 7: AP velocity varies with axon pearl dimensions.
From: Membrane mechanics dictate axonal pearls-on-a-string morphology and function
a-f, Plots showing the relationship between AP velocity and the ratio of two measured values like connector width/NSV width (a), connector width/NSV length (b), connector width/connector length (c), connector length/NSV length (d), NSV length/NSV width (e), and connector length/NSV width (f). The data are fitted by a simple linear regression in all except for e, which is fitted by a gaussian non-linear curve. g. Plot showing the predicted AP conduction velocity based on the dimensions of NSVs and connectors in neurons treated with sham (DMSO) or 50 µM Blebbistatin (bleb). h. Plot showing the AP conduction velocity from the experiments in (j). Mean and S.E.M. are plotted. Mann-Whitney U test (two-sided). N = 8 animals each, n = 12 slices.
