Extended Data Fig. 2: Manipulation of membrane mechanics predicts changes in axonal pearling.
From: Membrane mechanics dictate axonal pearls-on-a-string morphology and function
a. Axon morphology is modeled using classic Helfrich membrane model and governed by the membrane bending, surface tension, and osmotic condition. 3D model prediction of axon morphology in indicated osmotic conditions, tension of 0.001 mN/m, and bending rigidity of 50kBT. Scale bar: 200 nm. b. 3D model prediction of axon morphology at indicated bending rigidity, tension of 0.001 mN/m, and osmolarity 300 mOsm. Scale bar: 200 nm. c. Rotationally averaged shape profiles of axons under constant 0.001 mN/m tension and varying osmotic conditions and bending rigidity. The bead diameter (D) and length (L) in nanometers are given as a text inset for each condition. d. Rotationally averaged shape profiles of axons under constant 0.01 mN/m tension and varying osmotic conditions and bending rigidity. The bead diameter (D) and length (L) in nanometers are given as a text inset for each condition.
