Fig. 6: Synaptic loss and neurodegeneration in MAPTS305N;Int10+3 KI mice. | Nature Neuroscience

Fig. 6: Synaptic loss and neurodegeneration in MAPTS305N;Int10+3 KI mice.

From: In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds

Fig. 6

a, Representative super-resolution images of Homer1 and Synaptotagmin puncta colocalization in the entorhinal cortex layer II (EC-Lyll) of 16-month-old WT, MAPT KI, MAPTInt10+3 and MAPTS305N;Int10+3 KI mice. Scale bar, 5 µm. b, Quantification of Synaptotagmin/Homer1 colocalization density in the polymorph layer of the dentate gyrus (PoDG), CA3 stratum radiatum (CA3-Rad), CA1 lacunosum molecular layer (CA1-Lmol) and EC-LyII regions of 16-month-old WT, MAPT KI, MAPTInt10+3 and MAPTS305N;Int10+3 KI mice (n = 5–6 animals per genotype; n = 3 females and n = 2 or 3 males). c, Amino-cupric silver (AmCuAg) staining in the entorhinal cortices of 15-month-old MAPT KI, MAPTInt10+3 and MAPTS305N;Int10+3 KI mice. Scale bar, 50 µm. Black arrows, structures resembling neurites. d, Quantification of AmCuAg staining (MAPT KI, n = 4; MAPTInt10+ KI, n = 6; and MAPTS305N;Int10+3 KI, n = 8; sex matched per genotype). In b, data represent mean ± s.e.m. (two-way ANOVA with Tukey’s multiple comparison test). In d, data represent mean ± s.e.m. (Kruskal–Wallis one-way ANOVA test with Dunn’s multiple comparison test).

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