Fig. 8: Perseverative, disinhibition behaviors and apathy indicated in MAPTS305N;Int10+3 KI mice. | Nature Neuroscience

Fig. 8: Perseverative, disinhibition behaviors and apathy indicated in MAPTS305N;Int10+3 KI mice.

From: In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds

Fig. 8

a–c, Number of trials to reach criteria and nosepokes of 14- to 16-month-old WT, MAPT KI, MAPTInt10+3 KI and MAPTS305N;Int10+3 KI mice in the CS/PS-shuffled session of SP-FLEX (WT, n = 14; MAPT KI, n = 11; MAPTInt10+3 KI, n = 15; MAPTS305N;Int10+3 KI, n = 10). d–f, Percentage of premature responses displayed by 14- to 16-month-old WT, MAPT KI, MAPTInt10+3 KI and MAPTS305N;Int10+3 KI mice in sessions 2–3 of the behavioral inhibition test (WT, n = 12; MAPT KI, n = 11; MAPTInt10+3 KI, n = 15; MAPTS305N;Int10+3 KI, n = 9). g–i, Percentages of saccharin choice made by 14- to 16-month-old WT, MAPT KI, MAPTInt10+3 KI and MAPTS305N;Int10+3 KI mice in the taste preference test and the subsequent effort-based choice test (WT, n = 11; MAPT KI, n = 11; MAPTInt10+3 KI, n = 14; MAPTS305N;Int10+3 KI, n = 9). In c, e, f and i, data represent mean ± s.e.m. (two-way ANOVA with Tukey’s multiple comparison test). For i, The P value shown is the one comparing WT with MAPTS305N;Int10+3 KI (see source data for results on all comparisons). Illustrations in d and g created using BioRender.com.

Source data

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