Extended Data Fig. 4: Correlation between distances of amino acid pairs and LH domain principal components.
From: NOMPC ion channel hinge forms a gating spring that initiates mechanosensation
Correlation coefficients between the Cα-Cα distances of the three amino-acid pairs that were converted into cysteine pairs to generate LH+LHCys-NOMPC::GFP (Fig. 5 and Extended Data Fig. 5) and the principal components (PCs) of the LH domain in equilibrium (left), pushing (middle) and pulling (right) simulations. Correlation coefficients whose absolute values exceed 0.5 are highlighted in blue. The positions of the respective amino-acid pairs and their Cα-Cα distances in equilibrium (without forcing) and non-equilibrium (with pushing force) simulations are indicated in Fig. 5b.
