Fig. 3: Oligodendrocyte and myelin damage in AD.
From: Oligodendrocytes in Alzheimer’s disease pathophysiology
a,b, Myelin and oligodendrocyte pathology, including focal areas of demyelination around amyloid plaques, damage to white matter tracts and changes in myelin ultrastructure, has been detected in different AD mouse models. a, Myelin basic protein (MBP) (magenta) around amyloid plaques (cyan) in 5xFAD animals aged 10 months. b, Scanning electron microscopy image shows abnormal myelin (green) in the corpus callosum of 5xFAD animals aged 10 months. Scale bars, 10 µm (a) and 1 µm (b). c, Oligodendrocytes under pathological conditions transition to a disease-associated oligodendrocyte state, marked by upregulation of Serpina3n and C4b. Image shows SERPINA3N (cyan)-positive oligodendrocytes (magenta) around amyloid plaques (yellow) in the cortex of 5xFAD animals aged 10 months. Scale bar, 10 µm. Figure created using BioRender.com.
