Extended Data Fig. 5: Activity patterns of D1 and D2 neurons and individual variability.
From: Dopamine in the tail of the striatum facilitates avoidance in threat–reward conflicts
(a) Location of optic fiber tips used to collect D1 neuron activities (left) and D2 neuron activities (right) in TS. Fiber tip positions are plotted on the nearest reference slice (Paxinos and Franklin, 2019). (b) D1 and D2 neuron activity in the control sessions with no monster. Top, mean ± SEM. (c) Average neural responses in monster sessions. Both D1 and D2 neurons were activated at monster movement (p = 0.012, −1 to 0 s before monster movement, p = 1.3 × 10−3, 0-1 s after movement, D1, n = 12 animals; p = 2.9 × 10−3, before movement, p = 1.6 × 10−3, after movement, D2, n = 11 animals, two-sided t-test). Center of box plot shows median; edges are 25th and 75th percentiles; and whiskers are the most extreme data points. (d) Predictive avoidance rate vs average D1 and D2 neuron responses before (left) and after (right) monster movement in each animal (average of 10 monster sessions, R = 0.53, p = 0.077, 0-1 s before monster; R = 0.89, p = 1.2 × 10−4, 0.1-1.1 s after monster, n = 12 animals, D1; R = −0.61, p = 0.047, before monster; R = −0.28, p = 0.41, after monster, n = 11 animals, D2, Pearson’s correlation coefficient). (e) Reactive avoidance rate vs average D1 and D2 neuron responses before (left) and after (right) monster movement in each animal (average of 10 monster sessions, R = 0.40, p = 0.11, 0-1 s before monster; R = 0.78, p = 2.8 × 10−3, 0.1-1.1 s after monster, n = 12 animals, D1; R = −0.59, p = 0.058, before monster; R = −0.24, p = 0.47, after monster, n = 11 animals, D2, Pearson’s correlation coefficient). *P < 0.05.
