Extended Data Fig. 6: Predictive and reactive avoidance in D1 and D2 neuron ablation mice.
From: Dopamine in the tail of the striatum facilitates avoidance in threat–reward conflicts
(a) Extent of bilateral ablations of D1 (top) and D2 (bottom) neurons in TS. Ablation areas are marked with orange (D1, n = 6) or green (D2, n = 12) shading, with overlapping shading from ablation mice. More densely overlapping areas have darker shading. Ablation areas are marked on the nearest reference slice (Paxinos and Franklin, 2019). (b) Time-course of predictive avoidance across trials in D1 (top) and D2 (bottom) neuron ablation and control mice. Error bars, SEM (binomial). (c) Time-course of predictive avoidance across sessions in D1 (top) and D2 (bottom) neuron ablation and control mice. Error bars, SEM. (d) Predictive avoidance of D1 neurons ablation mice was significantly lower than that of control, while D2 ablation mice show opposite tendency (p = 0.045, D1, two-sided t-test, n = 6 animals for each; p = 0.16, D2, two-sided t-test, n = 12 animals for each; p = 0.028, D1 vs D2 ablation, two-sided t-test). Center of box plot shows median; edges are 25th and 75th percentiles; and whiskers are the most extreme data points. (e) Time-course of reactive avoidance across trials in D1 (top) and D2 (bottom) neuron ablation and control mice. Error bars, SEM (binomial). (f) Time-course of reactive avoidance across sessions in D1 (top) and D2 (bottom) neuron ablation and their control mice. Error bars, SEM. (g) Reactive avoidance of D1 neuron ablation mice was significantly lower than that of control, while D2 ablation mice show opposite tendency (p = 3.7 × 10−3, D1, two-sided t-test, n = 6 animals for each; p = 0.12, D2, two-sided t-test, n = 12 animals for each; p = 0.016, D1 vs D2 ablation, two-sided t-test). Center of box plot shows median; edges are 25th and 75th percentiles; and whiskers are the most extreme data points. *P < 0.05.
