Fig. 2: Value and intensity modulation of dopamine responses in the striatum.
From: Dopamine in the tail of the striatum facilitates avoidance in threat–reward conflicts
a, Left: AAV9-Syn-GRABDA2m was injected, and an optic fiber was implanted in various areas of the striatum (66 animals, one recording site per animal). Right: three different intensities of pure tone (50, 75 and 100 dB) and three different sizes of water (1, 3 and 10 μl), pseudorandomly presented to the head-fixed mice during the fiber fluorometry recording. WT, wild type. b, Top: dopamine responses (0–1 s) to water and tone in example animals (anterior, ex1 (left); posterior, ex2 (right)). Bottom: dopamine responses to water (10 μl (left)) and to tone (100 dB (right)) across different locations of the striatum. The example animals are indicated by the arrowheads. c, The regression coefficients of dopamine responses with water sizes (R = −0.38, P = 1.6 × 10−3, Pearson’s correlation coefficient (left)) and tone intensities (R = 0.74, P = 4.6 × 10−13, Pearson’s correlation coefficient (right)) were plotted along the anterior–posterior axis in the striatum. d, The dopamine response types (Methods) with anatomical location in the striatum. e, The regression coefficients of dopamine responses with water sizes and tone intensities were anticorrelated (R = −0.53, P = 2.8 × 10−6, Pearson’s correlation coefficient). f, The dopamine response types were mapped onto an anatomical map of the striatum62. g, Dopamine responses to tone (top) and water (bottom) in the ventral striatum (VS), the dorsomedial striatum (DMS), the DLS, posterior DLS/aTS (anterior to Bregma −1.5 mm) and TS (mean ± s.e.m.). h, The average dopamine responses to water (left) and tone (right) in VS, DMS, DLS, aTS and TS (n = 66 animals). The error bars represent the s.e.m.
