Fig. 6: Ventral subiculum inactivation affects behavior during learning of a new problem.
From: Hippocampal output suppresses orbitofrontal cortex schema cell formation
a,b, Percentage correct (a) and trial initiation latencies (b) across days of learning for rats in the control and GtACR2 groups. The ANOVAs revealed significant effects of session, trial type, group, an interaction between session and trial type, and an interaction between trial type and group (F > 5.4; P < 0.021; \({{{\eta }}}_{{\rm{p}}}^{2}\) > 0.03; n = 10 d for both control and GtACR2) in the percentage correct, reflecting quicker development of the no-go response on nonrewarded positions in the inactivated group at the early stages of learning (days 2–6) (− in scatter plots: t53 = 2.7; P = 9.4 × 10−3; two-tailed Student’s t-test; n = 28 for control; n = 27 for GtACR2) and a significant main effect of trial type and an interaction between group and trial type (F > 5.8, P < 0.0007, \({{{\eta }}}_{{\rm{p}}}^{2}\) > 0.043; n = 10 d for both control and GtACR2) in the trial initiation latencies, reflecting a failure of rats in the inactivated group to distinguish the two nonrewarded positions (P1 versus P2 in the scatter plots) (control: t104 = 5.2, P = 1.2 × 10−6; n = 53 sessions; GtACR2: t104 = 0.29, P = 0.77; two-tailed Student’s t-test; n = 53 sessions). −, nonrewarded trials; +, rewarded trials. The error bars are the s.e.m. (***P < 0.001; **P < 0.01).
