Extended Data Fig. 6: Additional characteristics of CA1 PC remapping.
From: Mechanisms of experience-dependent place-cell referencing in hippocampal area CA1
a, The correlation between the Vm COM and PF COM in Pre. The green line is a two-sided linear fit (n = 26 cells, p = 1.5 × 10–20, R2 = 0.97). b, PF remapping of 26 recorded CA1 PCs. The reward is at 184 cm and 92 cm before (Pre) and after (Post) the reward switch, respectively. The dashed lines indicate the distribution center of goal- and space-referenced cells. The black, blue, and red dots indicate the intermediate, space-, and goal-referenced PCs, respectively. c, The correlation between the Vm COM and PF COM in Post. The green line is a two-sided linear fit. (n = 26 cells, p = 1.2 × 10–21, R2 = 0.98). d, The fraction of PCs as a function of shifted PF distance after the reward switch. The black and green lines represent imaging and whole-cell data, respectively (p = 0.18, two-sample two-sided Kolmogorov–Smirnov test). e, An example cell demonstrating the split of a place field into goal- and space-referenced Vm ramps immediately following reward switch. Left: The shaded heatmap shows the Vm in space across trials before (Pre) and after (Post) the reward switch. The dashed lines indicate the reward locations (at 184 and 92 cm in Pre and Post, respectively). Right: The averaged Vm of Pre (gray) and Post (black) trials. The blue and red dashed lines indicate the original (space-referenced) PF and the Goal PF (92 cm away from the original PF), respectively. Bottom: The mean spatial firing rate of the cell in Pre (gray) and Post (black) trials. f, The Goal/Space index as a function of PF COM in Pre. The reward is at 184 cm in Pre. The green line is a two-sided linear fit (n = 25 cells, p = 0.08, R2 = 0.13). g, The correlation between the PF COM before spontaneous plateaus and the location of spontaneous plateaus. The green line is a two-sided linear fit (n = 35 plateaus, p = 0.37, R2 = 0.024).
