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RNA dysregulation impairs stress resilience in aged neurons

Nature Neuroscience volume 28, pages 1124–1125 (2025)Cite this article

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Aging is a primary risk factor for neurodegenerative diseases. This study shows that key RNA pathways are disrupted in old neurons, including splicing and the stress response. Because of these changes, the aging brain has reduced resilience to new stress, which might predispose old neurons to disease.

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Fig. 1: RNA dysregulation in aged neurons.

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This is a summary of: Rhine, K. et al. Neuronal aging causes mislocalization of splicing proteins and unchecked cellular stress. Nat. Neurosci. https://doi.org/10.1038/s41593-025-01952-z (2025).

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RNA dysregulation impairs stress resilience in aged neurons. Nat Neurosci 28, 1124–1125 (2025). https://doi.org/10.1038/s41593-025-01953-y

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