Extended Data Fig. 4: Gene expression levels of orexin-mediated GPCR signaling molecules. | Nature Neuroscience

Extended Data Fig. 4: Gene expression levels of orexin-mediated GPCR signaling molecules.

From: Lemborexant ameliorates tau-mediated sleep loss and neurodegeneration in males in a mouse model of tauopathy

Extended Data Fig. 4

a–i, Gene expression levels of orexin receptors and downstream effectors in naïve male P301S/E4 mice compared at ZT3 and ZT13 (n = 6 mice/group; a–d, f–i, two-tailed t test; e—Mann–Whitney test), and (j–r) Veh- and Lem-treated male mice (j—nVeh = 9, nLem ZT3 = 7, nLem ZT13 = 7; one-way ANOVA and Dunnett’s post hoc test; k—nVeh = 9, nLem ZT3 = 7, nLem ZT13 = 7; Kruskal–Wallis test and Dunn’s post hoc test; l—nVeh = 8, nLem ZT3 = 7, nLem ZT13 = 7; Kruskal–Wallis test and Dunn’s post hoc test; m—nVeh = 8, nLem ZT3 = 7, nLem ZT13 = 7; one-way ANOVA and Dunnett’s post hoc test; n—nVeh = 9, nLem ZT3 = 7, nLem ZT13 = 7; Kruskal–Wallis test and Dunn’s post hoc test; o—nVeh = 9, nLem ZT3 = 7, nLem ZT13 = 7; one-way ANOVA and Dunnett’s post hoc test; p—nVeh = 9, nLem ZT3 = 7, nLem ZT13 = 7; one-way ANOVA, p = 0.5522; Dunnett’s post hoc test; q—nVeh = 9, nLem ZT3 = 7, nLem ZT13 = 7; Kruskal–Wallis and Dunn’s post hoc test; r—nVeh = 9, nLem ZT3 = 7, nLem ZT13 = 7; one-way ANOVA and Dunnett’s post hoc test). For detailed statistical information, see Supplementary Table 1. Data represent mean ± s.e.m. of biological replicates.

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