Fig. 5: Proteomics analysis identifies dysregulated synaptic proteins.
From: Evidence for trans-synaptic propagation of oligomeric tau in human progressive supranuclear palsy
a,b, Volcano plots highlighting the results of proteomic analysis comparing synaptic enriched fractions from PSP and control SN (a) and frontal cortex (b). DEPs were defined as P < 0.05 and a 20% change in protein level. Downregulated proteins are shown in red. Upregulated proteins are shown in blue. Proteins that were not differentially expressed are highlighted in gray. SynGO analysis was conducted on the synaptic enriched fraction preparations from the SN (b,c) and frontal cortex (d,e). c,d, In the SN, there are very few upregulated proteins (c) and a substantial loss of presynaptic and postsynaptic proteins (d). e,f, In the frontal cortex, there are similar numbers of upregulated (e) and downregulated (f) proteins.
