Extended Data Fig. 5: Transcription factor interaction analysis in subnetworks.
From: Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice
Subnetwork for APs (a), BPs (b) and precursors (c). Each subnetwork is merged across e12.5 and e16.5, with node color indicating the difference in expression between stages. The size of nodes reflects the number of downstream targets per TF. Subnetworks show only interaction between TFs. d, Dot plot showing cosine score on the y-axis and TF pairs on the x-axis. Color and size indicate the stage and the number of occurrences of TF1-TF2, respectively. e, Genomic view of transcription factor binding sites for NFIB-MEIS2 and NFIB-TCF4. f, TF interaction network of TFs that regulate genes dynamic along the maturation trajectory in e12.5. Nodes are colored by their average expression at e12.5. g, TF interaction network showing transcription factors (TFs) regulating genes with dynamic expression along the maturation trajectory at e16.5. Nodes are colored based on their average expression levels at e16.5. h, Number of bound genes per TF (out-degree) at e12.5 and e16.5; subsetted for genes dynamic along the maturation trajectory and their upstream TFs. TFs with an out-degree higher or equal than eight are labelled.
