Extended Data Fig. 4: Representative images of C. elegans expressing GFP alone or α-syn and GFP.
From: Hypoxia ameliorates neurodegeneration and movement disorder in a mouse model of Parkinson’s disease
C. elegans normally have four DA CEP neurons in the head. In animals grown in 21% O2, four DA CEP neurons are present in the wild-type animal (dat-1::gfp) and three visible in this focal plane. Only three DA neurons are present in the transgenic animal expressing α-syn (dat-1::α-syn + dat-1::gfp). Lower GFP fluorescence in the α-syn-expressing animal is indicative of neurons in the process of degeneration.
