Fig. 2: Hypoxia prevents PFF-induced tissue hyperoxia and lipid peroxidation in the SNpc of mice.
From: Hypoxia ameliorates neurodegeneration and movement disorder in a mouse model of Parkinson’s disease
a, Representative photomicrograph of Perls-DAB-stained SNpc in mice treated with PFF or α-syn monomer and breathing 21% or 11% O2 for 12 weeks. b, Ratio of Perls-DAB+ area to SNpc area in mice treated with PFF or α-syn monomer and breathing 21% or 11% O2 for 12 weeks. a,b, n = 4 for mice injected with α-syn monomer; n = 11 or 12 for mice injected with PFF. c, Brain tissue pO2 in the SNpc of mice treated with PFF or α-syn monomer and breathing 21% or 11% O2 for 6 weeks. n = 6 in each group. d, MDA levels in the SN of mice treated with PFF or α-syn monomer and breathing 21% or 11% O2 for 6 weeks. n = 6 in each group. A two-way ANOVA followed by Tukey’s correction for post-hoc comparisons was conducted. b–d, Data are presented as box plots showing the median and IQR, with the whiskers denoting the maximum and minimum values. a, Scale bars, 100 μm. SNpr, substantia nigra pars reticulata.
