Fig. 4: Breathing 11% O2 remains beneficial 10 months after PFF-induced α-syn aggregation.
From: Hypoxia ameliorates neurodegeneration and movement disorder in a mouse model of Parkinson’s disease
a, Schematic depicting the experimental groups and timeline. b,c, Results of the pole (b) and cage hang (c) tests in mice treated with PFF or α-syn monomer and exposed to 21% or 11% O2 for 10 months. b,c, The number of mice in each group was 21% O2, monomer (n = 8); 21% O2, PFF (n = 6); 11% O2, monomer (n = 8); and 11% O2, PFF (n = 7). d, Relative gene expression levels of Vegfa, Kdr and Adm in the SN of mice treated with PFF or α-syn monomer and exposed to 21% or 11% O2 for 10 months. The number of mice in each group was 21% O2, monomer (n = 8); 21% O2, PFF (n = 5 for Vegfa, n = 6 for Kdr and Adm); 11% O2, monomer (n = 8); and 11% O2, PFF (n = 7). b–d, A two-way ANOVA followed by Dunnett’s correction for post-hoc comparisons was conducted. Data are presented as box plots showing the median value and IQR, with the whiskers denoting the maximum and minimum values.
