Fig. 5: Hypoxia prevents the loss of DA neurons in C. elegans overexpressing α-syn.
From: Hypoxia ameliorates neurodegeneration and movement disorder in a mouse model of Parkinson’s disease
a, Schematic depicting the experimental groups and timeline. b, Percentage of C. elegans in which at least one DA cephalic (CEP) neuron is absent at day 7 of adulthood. Each point represents one cohort in which approximately 30 animals were analyzed (the number of C. elegans in each group was 21% O2, GFP (n = 80); 21% O2, α-syn (n = 84); 1% O2, GFP (n = 82); and 1% O2, α-syn (n = 81)). b, Data are presented as a box plot showing the median and IQR, with the whiskers denoting the maximum and minimum values. A Fisher’s exact test was conducted to compare each of two groups with a two-sided P value.
