Extended Data Fig. 9: Clustering analysis of RGC responses of human fovea and periphery and their action potential propagation speeds.

a, UMAP projection of both foveal and peripheral RGC data, clustered into 12 distinct color-coded groups based on their functional properties (N = 1093 cells). The dashed line separates On, On–Off and Off cells. b,c, Same UMAP projection as in a (gray dots) with cells from the fovea (b, N = 347) and periphery (c, N = 746) marked by colors. Same color scheme as in a. Median propagation speeds (v, m s⁻¹) and standard deviations are reported for each cluster. Standard deviations are not given for three clusters, which contained only a single cell. d, Normalized firing rates (averaged over trials and coded by color) of all RGCs depicted in a as rows in response to the stimulus depicted above. Each panel represents a single cluster, with foveal RGC responses shown at the top and peripheral responses below. Light and dark gray shading at the left indicates foveal (light gray) and peripheral (dark gray) cells in each cluster. e, Box plots of action potential propagation speeds (individual data points overlaid). The number of samples for each box plot is indicatedN, and the colors correspond to the clusters shown in panels a–c. Box plots show extrema, 25th and 75th percentiles and median. Some clusters show paired data for fovea and periphery, while others represent only one region. Color shading below the cluster numbers indicates foveal (light gray) and peripheral (dark gray) data for each cluster.

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