Fig. 5: Brief synchronous spiking by PV cells, precedes PV and SST hyperpolarization and synchronizes rebound activity at theta peaks.
From: Voltage imaging reveals hippocampal inhibitory dynamics shaping pyramidal memory-encoding sequences
a, Example trace of a PV cell around the first odor of a series of DNMS trials, displayed as before. Note the brief ‘onset spiking’, preceding the hyperpolarization in some, but not all, trials. b, Spikes of pooled PV field cells (light blue) and no-field cells (dark) around the first odor across all trials (top). Average finescale firing rates (binned at 5 ms) of the two cell groups aligned to the mean ΔF/F of all PV cells (blue trace) and its theta power-bandpassed signal (gray trace) (bottom). The three vertical lines are aligned to the first spike peak and the two theta peaks, respectively. c, Same for pooled SST cells. The three vertical lines indicate the same time points as in b. d, Mean firing rates at onset spiking (30–50 ms after odor onset) in field cells versus no-field cells (PV, 58 versus 49 cells; SST, 45 versus 48 cells). P = 0.403, 0.388; two-sided WT. e, Same for rebound spiking (200–500 ms after odor onset). P = 0.0004, 0.004; two-sided WT. f, Firing increase from baseline (0.5 s pre-odor) at onset and rebound spiking in PV versus SST cells (n = 107, 93 cells). P = 4.97 × 10−4, 0.89; two-sided WT. Single outlier truncated at d and f for plotting clarity.
