Supplementary Figure 7: Comparison of ligand binding pockets within the TRPV subfamily
From: Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM
a The transmembrane domain (TMD) of TRPV5ECN. Bound econazole (ECN) is represented as yellow sticks. The regions of TRPV5ECN are colored based on the diagram in Fig. 1b. b The TMD of rat TRPV1 solved in nanodiscs in the absence of added ligand (purple, PDB: 5IRZ). Bound phosphatidylinositol, a lipid cofactor of TRPV1, is shown in grey sticks. c The TMD of rat TRPV1 solved in nanodiscs in the presence of the inhibitor capsazepine (orange, PDB: 5IS0). The capsazepine molecule (CPZ) is shown in grey. d The TMD of rat TRPV1 solved in nanodiscs in the presence of the potent agonists, resiniferatoxin (RTX) and double-knot toxin (DkTx) is shown in red (PDB: 5IRX). The pocket depicted coordinates an RTX molecule (grey).
