Supplementary Figure 13: Distance analysis of H3 tails within the PRC2–DiNcl35 complex
From: Cryo-EM structures of PRC2 simultaneously engaged with two functionally distinct nucleosomes
Distances of H3 tails within the PRC2-DiNcl35 cryo-EM structure discussed in this study and the H3K4 binding site within RBAP48 (yellow circle). Only the direct connections made by the H3 tails from the nucleosome to the active site (H3sub) or EED (H3mod) are in good agreement with the distance that can be bridged by the respective number of residues without major clashes (green lines). Red indicates distances too large to be bridged by the histone tails. Orange, theoretically possible connections to RBAP48, but ruled out due to major clashes within PRC2.
