Supplementary Figure 4: Classification of images for the 247DLIIKGISVHI257 cryo-EM sample.
From: Atomic-level evidence for packing and positional amyloid polymorphism by segment from TDP-43 RRM2
(a) Round 1 classification illustrates the polymorphic assemblies observed in the fibril sample. (b and c) Round 2 and 3 class averages focus on fibrils exhibiting the 3-start helix morphology. Each panel illustrates a unique face of the fibril as it twists along the EM grid. 5-7Å features of the structure become apparent during these rounds of class averaging.
