Supplementary Figure 4: Fit of the model to the density of the ABCG2–MZ29–Fab complex.
From: Structural basis of small-molecule inhibition of human multidrug transporter ABCG2
a, Fit of the TM helices of the final model of the ABCG2 TMD to the post-processed and masked map from RELION. A region of up to 2 Å around the atoms is shown. b, Same as a but showing the intramolecular disulfide (C592-C608), the intermolecular disulfide (C603-C603’) and N596 decorated with two GlcNAcs. c, Same as a but showing the Walker A motif with selected residues numbered. d, Same as a but showing the Walker B motif and the D loop. e, Same as a but showing the α-helix containing Q141 with selected residues numbered. f, Same as a but showing the fit of MZ29 and surrounding residues.
