Supplementary Figure 3: Structure families of amyloid fibrils.
From: Atomic structures of FUS LC domain segments reveal bases for reversible amyloid fibril formation
The amyloid fibril spine of Tau VQIVYK represents a typical steric-zipper architecture shared by pathogenic amyloid fibrils (highlighted in green). PSMα3 has been recently found to form amyloid fibrils with α-helices rather than β-strands (highlighted in blue). The amyloid fibril spines of RAC1 showed a distinctive structure with no regular secondary structures (highlighted in orange). The amyloid fibril spines of RAC2 harbors water molecules between the interface of mating sheets rather than typical dry interface as seen in steric zippers (highlighted in yellow). PDB ID of VQIVYK is 2ON9. PDB ID of PSMα3 is 5I55.
