Supplementary Figure 3: Clr6 histone deacetylase complex regulates expression of iron transporter genes.
From: Iron homeostasis regulates facultative heterochromatin assembly in adaptive genome control
(a) Area proportional Venn diagrams representing the numbers of genes with increased expression (fold change value ≥ 1 and P value < 0.05) in clr6-1 mutant cells grown at 30 °C and wild-type cells grown at 18 °C (top) or clr6-1 cells grown at 30 °C and clr4Δ cells grown at 18 °C (bottom). Statistical significance (right-hand, single-tailed P value of binomial distribution, n=6380 transcripts) of the overlap between the two groups is shown above. (b) Expression levels of six representative iron transporter genes determined by RNA-seq are shown in wild-type and clr6-1 cells grown at 30 °C. (c) Pst1-HA and Clr6-HA relative enrichment in cells grown at 30 °C was determined by ChIP-chip and is shown for iron transporter genes.
