Supplementary Figure 1: Current model showing the roles of RNA processing factors in the degradation of transcripts and facultative heterochromatin assembly.
From: Iron homeostasis regulates facultative heterochromatin assembly in adaptive genome control
RNA binding proteins engage a network of nuclear RNA processing factors such as MTREC and CCR4-NOT, which in turn act along with the termination factor Dhp1/Xrn2 to promote degradation of RNAs by the exosome and/or RNAi machinery. In addition to RNA degradation, these factors are believed to mediate recruitment of histone H3 lysine 9 methyltransferase Clr4 to promote the assembly of facultative heterochromatin islands.
