Supplementary Figure 5: Extensive ubiquitination of proteins from the non-membrane-bound organelle proteasome and centrosome.
From: UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites
a, Correlation of ubiquitination site changes on proteasomal and centrosomal proteins between bortezomib (BOR) and b-AP15 (AP15) treatment within the same cell line. R refers to Spearman correlation. b, Correlation of bortezomib- or b-AP15-induced changes on the proteasomal and centrosomal ubiquitination sites between the two cell lines. R refers to Spearman correlation. c, An average number of ubiquitination sites per protein on the EUPs from the proteasome and centrosome in the current UbiSite dataset and in the study by Udeshi et al. (Mol. Cell. Proteomics 12, 825–831, 2013). The average numbers of significantly regulated sites per protein in response to proteasomal inhibition are indicated as well. d,e, Comparison of the significantly regulated ubiquitination sites on proteasomal (d) and centrosomal (e) EUPs from the two studies.
