Supplementary Figure 3: Ubiquitination is distributed over the entire proteome.
From: UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites
a, Hierarchical clustering of pairwise Spearman’s correlation coefficients between each replica and experiment. The results are plotted as heat maps for the total proteomes (top) and for all ubiquitination sites from the LysC followed by trypsin dataset (bottom). b, GO term biological processes (GOBP), molecular functions (GOMF) and cellular component (GOCC) enrichment of the total proteome and the UbiSite-enriched ubiquitinome. c, SILAC-based quantification of ubiquitin chain peptides in response to bortezomib (BOR) and b-AP15 (AP15) relative to control (CTR) for Jurkat and Hep2 cells based on three and four biologically independent experiments, respectively. Bars represent the corresponding SILAC ratios (mean + s.d.)
