Supplementary Figure 4: Normalized HiC interaction frequencies for interactions between the HoxB cluster and other clustered genes.
From: Smchd1 regulates long-range chromatin interactions on the inactive X chromosome and at Hox clusters
a. Normalised Hi-C interaction frequencies at 50kb, 500 kb and 1Mb resolution displayed as a heat map and rotated 45o for Chr11:96–100Mb containing the HoxB and Keratin gene clusters. Above the horizontal is the Smchd1fl/fl heatmap, below the horizontal Smchd1del/del. The colour of the contact map, from blue to red, indicates the log2(contact frequency). Dotted white/black regions indicate the region of differential interaction, which is visible in the analyses at all 3 resolutions. b. Heatmaps displayed as in a, at 100kb resolution, for the region between the Olfactory receptor cluster genes (73 Mb) and HoxB cluster (97 Mb) on chromosome 11. Between the heatmaps, genes are shown as bars (green for Olfactory receptor genes), Smchd1 ChIP-seq peaks are shown as black bars. The white boxes bound the DIs with one anchor in the HoxB cluster. The magenta boxes are all other DIs in the region.
