Supplementary Figure 5: Depletion of DNA methylation is independent of R-loop formation.

Plot showing the average methylation profile centered around BG4 peak regions overlapping with R-loop regions (BG4 + R-loop, red and blue are replicates 1 and 2, respectively, n = 5,464) or BG4 peak regions without overlapping R-loop (BG4 – R-loop, pink and green are replicates 1 and 2, respectively, n = 3,111). The plot extends ±5 kb from the center of BG4 peaks.