Supplementary Figure 8: Naturally occurring proteins with the most similar structures or sequences to design BH_10.
From: De novo design of a non-local β-sheet protein with high stability and accuracy
a, The three closest structural analogs identified with DALI (Nucleic Acids Res. 44, W351–W355, 2016) are homodimers. The sequence identity over structurally aligned regions ranged from 7 to 19%. b, The three protein domains most similar in sequence and with structure available, as identified with HHpred (J. Mol. Biol. 430, 2237–2243, 2018) are also homodimers or part of a larger structure. For these three proteins, the sequence identity with BH_10 was 21% and E-values ranged between 0.14 and 0.39. Each chain is colored differently. The natural proteins identified all exhibit more irregular secondary structures, longer loops and extra elements building protein interfaces
