Supplementary Figure 6: Position of COX7B would not preclude interactions via COX4-1 in a mammalian CIII–CIV SC.
From: Structure of yeast cytochrome c oxidase in a supercomplex with cytochrome bc1
a,b, Side (a) and top (b) view of a putative mammalian III2IV1 SC formed after substitution of the yeast CIV monomer (CIVa) with bovine CIV (PDB 1V54) as per our III2IV2 SC structure (the other CIV is not shown). COX7B (blue), a subunit of mammalian CIV, lies near COX4-1 (pale cyan; the homolog of yeast Cox5A). However, it would not interfere with any interactions between CIII and COX4-1, such as those seen in the yeast III2IV2 SC structure. COX7A (deep red), the subunit involved in interactions with CIII in the mammalian I1III2IV1 respirasome, is also highlighted.
