Extended Data Fig. 8: Juxtaposition of SERINC5 and the trimeric HIV-1 envelope spike.
From: A bipartite structural organization defines the SERINC family of HIV-1 restriction factors
The model of human SERINC5 is shown in gray cartoons with residues important for restriction highlighted in blue and modeled loops in transparent white. The illustrative model of full-length trimeric HIV-1 Env was assembled using PDB 6E8W (model 1; pinks) and PDB 5FUU (gp41 browns; gp120 purples). MPER (653−683) is shown in cyans. All structures are shown in cartoons; the membrane is in a cream color. a, Side-by-side comparison. b, Models shown in closer proximity. c, 90o rotation and zoom of model in b, showing that the distance between ECL5 and ECL3 is approximately the same distance (~30 Å) as that between MPER α-helices in gp41.
