Extended Data Fig. 4: Organization of the radial spoke head tetrameric core. | Nature Structural & Molecular Biology

Extended Data Fig. 4: Organization of the radial spoke head tetrameric core.

From: Structure of the radial spoke head and insights into its role in mechanoregulation of ciliary beating

Extended Data Fig. 4

a, Topology diagram of the fold common to RSP9 and the middle domains of RSP4 and RSP6. The core of the fold is indicated with a grey background. Segments outside the core vary between the three proteins and are shown as they appear in RSP9. b, Three-dimensional structure of RSP9 colored according to the diagram in a. c, A helix-loop-helix motif found at the N-terminus of the RS head fold is used by all chains to dimerize with a neighboring subunit (RSP4 with RSP6 and RSP9 with itself, creating a homodimer). The RSP4-RSP6 dimer is shown as an example.

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