Extended Data Fig. 4: Map and model features of the Mec1-Ddc2 complex.
From: Mechanism of auto-inhibition and activation of Mec1ATR checkpoint kinase
a, 2D classes of Mec1-Ddc2 after a focused 3D refinement masking on Mec1-Ddc2 heterodimer, showing intrinsic flexibility of the complex across the dimer interface. b, Electron density features of the bound AMP-PNP, and c, strong electron density (unsharpened map) showing the PRD-I interaction with the activation loop at two points (asterisked). d, Map to model FSC curves.
