Extended Data Fig. 7: Global and kinase domain structural comparisons of Mec1-Ddc2.
From: Mechanism of auto-inhibition and activation of Mec1ATR checkpoint kinase
a-d, Structural comparisons between the Mec1 model (a,b) and Ddc2 model (c,d) from this study and the PDB:5X6O showing the global differences in N-terminal domains of both proteins. e-g, Overall comparison between the kinase region of Mec1(F2244L) State I (gray) and State II (light gray), demonstrating that both states are very similar outside of the active site with an Rmsd = 0.3 Å. f-g, Electron density of the nucleotide binding site and different side chain conformations associated with State I and State II (see main text for details).
