Extended Data Fig. 6: Cryo-EM structure of the NTS-NTSR1-Gi complex in lipid nanodiscs and the interaction with lipid.
From: Cryo-EM structure of an activated GPCR–G protein complex in lipid nanodiscs
a, Three views of the cryo-EM density map of the NTS-NTSR1-Gi-cND complex in the canonical state. b, Three views of the cryo-EM density map of the NTS-NTSR1-Gi-cND complex in the noncanonical state. The maps in panels (a) and (b) are low-pass filtered to 5 Å and colored by subunit. c, Two views of NTS-NTSR1 surrounded by nanodisc density. The transmembrane helices are shown in cylinder representation using the rainbow coloring scheme. ICL2 and helix H8 are partially submerged in lipid.
