Extended Data Fig. 6: Mutation of the Ser residues of FUS-LC impairs the inhibition of Hsp27 to FUS-LC LLPS.
From: Hsp27 chaperones FUS phase separation under the modulation of stress-induced phosphorylation
a, Schematics show the Ser residues (green) of FUS-LC that are mutated into Ala (red). The mutation construct is named S/A. b, Turbidity measurements of FUS-LC WT (left) and S/A (right) in the presence of Hsp27. c, Comparison of the effect of Hsp27 on the LLPS of FUS LC-WT and S/A. The turbidity values are those in (b) at 4 °C. Data shown correspond to mean ± S.D., n = 3. *** p<0.001 by Student’s t-test.
