Extended Data Fig. 5: Agreement of rPrP^106–145 model with core density in rPrP^Res.

a, Fourier Shell Correlation (FSC) between half-maps (blue) and the map and model (green) with resolutions at FSC = 0.5 (black dotted line) and 0.143 (gray dotted line) noted. b, Agreement of turn region with density looking down the fibril axis and (c) a side view of the same region shows clear strand separation. d, Overall fit of model into density. e, Magnified view of protofilament interface showing spacing between backbones at the center of the interface is at the most tightly spaced region between G¹¹⁴ of one chain and G¹¹⁹ of its mate. f, Magnified view of linchpin region with inferred salt bridge between residues H¹¹¹ and D¹⁴⁴ that seal off the interior of each chain and a side view (g) of the same region showing 4.8 Å separation between strands.