Extended Data Fig. 1: Current model of structural architectures of APC/CCDH1–UBE2C and APC/CCDH1–UBE2S.
From: Ubiquitin chain-elongating enzyme UBE2S activates the RING E3 ligase APC/C for substrate priming
Schematic depicting the interplay of substrate ubiquitination mechanisms, including substrate priming, multiubiquitination, and Ub chain elongation, by APC/CCDH1, UBE2C, and UBE2S. Upon APC/C activation by CDH1 binding, catalytic core APC2WHB–APC11RING is mobile and exposed for UBE2C recruitment (1). APC/CCDH1–UBE2C structural architecture for substrate priming and multiubiquitination (2 and 3). APC/CCDH1–UBE2S structural architecture where APC11RING is repurposed and binds acceptor ubiquitin for K11-linked Ub chain elongation (4).
