Extended Data Fig. 1: Binding of different substrates to LmrP does not induce a large conformational change in the binding pocket. | Nature Structural & Molecular Biology

Extended Data Fig. 1: Binding of different substrates to LmrP does not induce a large conformational change in the binding pocket.

From: An embedded lipid in the multidrug transporter LmrP suggests a mechanism for polyspecificity

Extended Data Fig. 1

Limited variations in distance distribution are observed when comparing LmrP in the apo state (blue) and in the presence of Hoechst 33342 (green), ethidium bromide (red), roxithromycin (cyan), TPP+ (yellow), verapamil (gray) and tetracycline (magenta), using one probe on the extracellular face and one within the binding pocket. Distributions were normalized. Interspin distance is denoted by r, with P(r) indicating the distance probability.

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